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Amyotrophic Lateral Sclerosis
 

  • Les Turner ALS Walk for Life on Track to Raise $1M for Research, Patient Services, Education

    Les Turner ALS Walk for Life on Track to Raise $1M for Research, Patient Services, Education

    The Les Turner ALS Foundation had about 7,000 people on more than 200 teams support those affected by amyotrophic lateral sclerosis (ALS) at the Les Turner ALS Walk for Life, held Sept. 18 in Chicago. The Les Turner ALS Foundation was founded in 1977 to support research, patient care, and education about ALS, a rapidly progressive neuromuscular disease that affects […]

  • FDA Names Ibudilast an Orphan Drug as Possible ALS Treatment

    FDA Names Ibudilast an Orphan Drug as Possible ALS Treatment

    The U.S. Food and Drug Administration (FDA) has designated  MediciNova’s Ibudilast (MN-166) an orphan drug as a potential treatment for amyotrophic lateral sclerosis (ALS). Ibudilast is a first-in-class, orally bioavailable small molecule phosphodiesterase (PDE)-4 and -10 inhibitor and a macrophage migration inhibitory factor (MIF) inhibitor that suppresses pro-inflammatory cytokines and promotes neurotrophic factors. Ibudilast has been available on the Japanese […]

  • Researchers Probe Neurofilaments’ Potential as Biomarkers for ALS Progression

    Researchers Probe Neurofilaments’ Potential as Biomarkers for ALS Progression

    An analysis of previously published data suggests that neurofilaments in the blood and spinal fluid of people with amyotrophic lateral sclerosis (ALS) may be used to assess disease progression and neurodegeneration in general. Levels of the factor also were higher in ALS patients than in patients with diseases mimicking ALS, suggesting that neurofilament also might […]

  • 11th Anniversary of ‘Tradition of Hope’ Gala Raises Funds for ALS

    11th Anniversary of ‘Tradition of Hope’ Gala Raises Funds for ALS

    Augie’s Quest announced the 11th annual ‘Tradition of Hope’ gala event will be held Oct. 15 at the Beverly Hilton Hotel to raise funds for amyotrophic lateral sclerosis (ALS) research. Augie’s Quest is a cure-driven nonprofit effort dedicated to finding treatments and a cure for ALS. The effort was started by Augie Nieto, co-founder of Life […]

  • New Preclinical Data of Masitinib for ALS Presented at 4 Scientific Meetings This Year

    New Preclinical Data of Masitinib for ALS Presented at 4 Scientific Meetings This Year

    AB Science has been invited to present new preclinical studies on masitinib in the treatment of amyotrophic lateral sclerosis (ALS) at four international meetings this year. These were the main findings from the series of preclinical studies: Proof of concept data from the preclinical trials of masitinib showed that the investigational drug “targets neurotoxic aberrant glial cells by inhibiting CSF1R, providing […]

  • New ALS Classification System Needed for Better Care and Research, Scientists Argue

    New ALS Classification System Needed for Better Care and Research, Scientists Argue

    Amyotrophic lateral sclerosis (ALS) would benefit from a new classification system, according to a group of researchers who highlighted the shortcomings of current systems for diagnosing the disease and allocating patients to subtypes of the condition. The opinion article, “Amyotrophic lateral sclerosis: moving towards a new classification system,” published in the journal The Lancet Neurology, […]

  • Researchers May Have Solved ALS Molecular Misfolding Mystery

    Researchers May Have Solved ALS Molecular Misfolding Mystery

    Researchers have identified a factor that prevents SOD1 — a protein causing amyotrophic lateral sclerosis (ALS) in a proportion of patients — from misfolding. The finding may advance the development of new drug therapies to stop or slow progression of the disease. The study, “Endogenous macrophage migration inhibitory factor reduces the accumulation and toxicity of misfolded SOD1 […]

  • Antibodies Circulating in Blood May Serve as Biomarker for ALS, Disease Severity

    Antibodies Circulating in Blood May Serve as Biomarker for ALS, Disease Severity

    The presence of a certain type of proteins of the immune system in the blood may serve as a reliable biomarker for the diagnosis of amyotrophic lateral sclerosis (ALS), as well as the severity of the disease, according to a new study conducted by Japanese and American researchers. The study, “Anti-Sulfoglucuronosyl Paragloboside Antibody: A Potential […]

  • Irish Researchers Will Visit Latin America to Gather Data About Mixed Ancestry and ALS

    Irish Researchers Will Visit Latin America to Gather Data About Mixed Ancestry and ALS

    Researchers at Trinity College Dublin will head to Latin America to investigate whether the probability of developing amyotrophic lateral sclerosis (ALS) is reduced in people with mixed ancestry. This new project will examine the hypothesis that mixed ancestral backgrounds might protect a person from developing ALS. Researchers will set up new registers of the incidence of ALS, as […]

  • Early Signs of Bulbar Disease in ALS May Be Evident in Tongue’s Movement While Talking

    Early Signs of Bulbar Disease in ALS May Be Evident in Tongue’s Movement While Talking

    Researchers report that evaluating a person’s control of tongue movement during speech can help to diagnose bulbar disease, especially in its early stages, in patients with amyotrophic lateral sclerosis (ALS). ALS affects motor neurons in the brain, brainstem, and spinal cord. If patients show alterations in speech or swallowing abilities they are diagnosed with bulbar ALS. Indeed, […]

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