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  • Cognitive Impairment Comes Before Motor Degeneration in ALS, Study Shows

    Cognitive Impairment Comes Before Motor Degeneration in ALS, Study Shows

    A research team led by Diego Minciacchi of the University of Florence in Italy identified a population of neurons that might explain the cognitive alterations antecedent to motor symptoms in Amyotrophic Lateral Sclerosis (ALS). The study entitled, “Increased anxiety-like behavior and selective learning impairments are concomitant to loss of hippocampal interneurons in the presymptomatic SOD1(G93A) […]

  • ALS Patients’ Health Decisions Rely on Multiple Factors

    ALS Patients’ Health Decisions Rely on Multiple Factors

    A study at King’s College London with patients recruited from the South-East ALS Register in England concluded that decision-making processes for ALS patients are complex, multidimensional and need individualized treatment and more patient-focused support. The results were presented in a publication entitled: “Accepting or declining non-invasive ventilation or gastrostomy in amyotrophic lateral sclerosis: patients’ perspectives,” […]

  • MediciNova Reports Clinical Trial for Experimental ALS Drug is 50% Enrolled

    MediciNova Reports Clinical Trial for Experimental ALS Drug is 50% Enrolled

    Biopharmaceutical company MediciNova, Inc. recently completed enrollment of the first 30 patients with amyotrophic lateral sclerosis (ALS) for its clinical trial to evaluate the efficacy MN-166 (ibudilast). The company plans to add another 30 participants to ensure a more robust sampling size to thoroughly study the novel therapy. The study was designed to include a period of treatment to last six […]

  • Cell Metabolite Reduces Neuronal Death in ALS, Study Shows

    Cell Metabolite Reduces Neuronal Death in ALS, Study Shows

    In a new study entitled “Neuronal death induced by misfiled prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment,” researchers report that in protein misfolding neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Amyotrophic Lateral Sclerosis, neuronal death is triggered by the lack of nicotinamide adenine […]

  • RNA-Sequencing Uncovers New Genes Involved in ALS Neurodegeneration

    RNA-Sequencing Uncovers New Genes Involved in ALS Neurodegeneration

    In a new study entitled “Transcriptome profiling of expression changes during neuronal death by RNA-Seq,” a research team employed RNA-sequencing to identify novel genes that might help regulate the death of neurons, a characteristic of neurodegenerative diseases. The study was published in the journal Experimental Biology and Medicine. Vertebrate development of the nervous system requires the […]

  • United Spinal Association Demands Wheelchair Accessible Taxicabs in DC for Those With ALS, Other Spinal Conditions

    United Spinal Association Demands Wheelchair Accessible Taxicabs in DC for Those With ALS, Other Spinal Conditions

    The national nonprofit United Spinal Association is advocating along with the Washington DC Taxicab Commission (DCTC) for the implementation of the DC Taxicab Service Improvement Amendment Act of 2012’s regulations and an increase in taxis able to carry wheelchairs. The implementation of the rule may impact the lives of people suffering from several conditions, including amyotrophic lateral sclerosis (ALS), […]

  • Clinical Trial Will Explore Genetic identification of Familial and Sporadic Amyotrophic Lateral Sclerosis

    Clinical Trial Will Explore Genetic identification of Familial and Sporadic Amyotrophic Lateral Sclerosis

    Investigators at the Northwestern University Feinberg School of Medicine are currently enrolling participants for a clinical trial (ClinicalTrials.gov Identifier: NCT00821132), that aims to identify genes that increase risk for sporadic Amyotrophic Lateral Sclerosis (ALS) or cause inherited ALS. The study, entitled “Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia […]

  • OptiKira  To Develop Cell-Protective Therapeutics For Unfolded Protein Response

    OptiKira To Develop Cell-Protective Therapeutics For Unfolded Protein Response

    BioMotiv is a drug advancement accelerator associated with The Harrington Project, the University of California San Francisco (UCSF), and University of Washington, Seattle working on breakthrough discoveries and new therapeutics that have the potential to address unmet clinical needs. Recently, the accelerator announced the creation of a platform company, OptiKira, that will advance small molecule therapeutics to prevent cell death in some pathologies derived from unfolded or misfiled proteins, such […]

  • New App Uses ALS Patients with Speech Disabilities’ Own Voices to Help Them Communicate

    New App Uses ALS Patients with Speech Disabilities’ Own Voices to Help Them Communicate

    The first app for amyotrophic lateral sclerosis (ALS) patients who have begun to lose their speaking abilities was recently launched by UK company Therapy Box. The app was designed to substitute standard text-to-speech synthesis with a synthesizer based on the patient’s own voice. The Predictable 4 app has entered the ModelTalker program, at a cost of $140 annually, as a way of helping patients […]

  • Recent Genetics Research May Hold Clues to New ALS Treatments

    Recent Genetics Research May Hold Clues to New ALS Treatments

    Dr. Nancy Bonini A recent editorial published in the journal Neurology highlights the existing scope of clinical knowledge concerning genetic susceptibility that makes individuals prone to developing amyotrophic lateral sclerosis (ALS). The editorial content was based on a thorough review of the current literature conducted by ALS researchers and authors Dr. Nancy Bonini PhD, Florence […]

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